Blocking T cell sequestration
نویسندگان
چکیده
منابع مشابه
Blocking effect of lyt-2 antibodies on T cell functions
Monoclonal anti-Lyt-2 antibodies blocked effector function of cytotoxic thymus-derived (T) cells in the absence of added complement. Cytolysis of both allogeneic cells and syngeneic lymphoma or sarcoma target cells was inhibited at the level of the effector lymphocytes. Anti-Lyt-1 and anti-Thy-1 antibodies did not block killer cells. Proliferation of T cells in mixed lymphocyte culture was also...
متن کاملCytosolic Sequestration of Prep1 Influences Early Stages of T Cell Development
OBJECTIVE Prep1 and Pbx2 are the main homeodomain DNA-binding proteins of the TALE (three amino acid loop extension) family expressed in the thymus. We previously reported reduced Pbx2 expression and defective thymocyte maturation in Prep1 hypomorphic mice. To further investigate the role of this homeodomain DNA-binding protein in T cell development, we generated transgenic mice expressing the ...
متن کاملHepatic sequestration in sickle cell anemia.
INTRODUCTION Sickle cell anemia is a chronic debilitating disease affecting a significant portion of patients of African American origin. These patients present to the physicians with myriad of life threatening complications like acute chest syndrome, septic shock, decompensated congestive heart failure secondary to severe pulmonary hypertension, stroke, and multi-organ failure. However, there ...
متن کاملInhibition of Red Cell Sequestration by Cortisone
The effect of cortisone on the sequestration of (a) antibody-coated red cells and (b) incubated red cells was studied in rats. Cortisone administration inhibited the hepatic sequestration of red cells altered by non-immune as well as by immune injury. There was a latent period of 2 days between the institution of cortisone therapy and its first manifest effect on hepatic sequestration. The sple...
متن کاملHepatic sequestration in sickle cell anaemia.
Several episodes of acute hepatic enlargement associated with a dramatic fall in haemoglobin concentration were observed in two patients with sickle cell anaemia. No appreciable disturbances of liver function or signs of cardiac failure were evident. The most likely mechanism was sequestration of sickled erythrocytes in the liver. This complication, which may have a basis similar to that of spl...
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ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2018
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd.2018.171